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NAD+ and Longevity: What Does Science Say?
NAD+: The Molecule That Changed Our Understanding of Longevity
What if one of the most fascinating molecules in modern ageing research were not some exotic substance, but a natural component of virtually every cell in our body? We are talking about NAD+, a molecule that has attracted increasing attention in recent years from scientists studying cellular metabolism, energy, ageing and longevity.
Current scientific research clearly shows that NAD+ plays an important role in processes that take place in our cells every day.
What Is NAD+?
NAD+, or nicotinamide adenine dinucleotide, is naturally present in virtually all our cells. It is an important coenzyme in cellular metabolism and helps transfer energy during the reactions through which cells process nutrients.
However, NAD+ is not important only for energy production. It is also used by enzymes involved in cellular signalling, responses to stress and processes associated with DNA repair. This broad range of functions is one of the reasons why NAD+ has become an important topic in current healthy ageing and longevity research.
From Its Discovery in 1906 to Modern Longevity Research
The story of NAD+ began in the early 20th century during research into fermentation. Scientists gradually discovered that this molecule was not merely involved in a single chemical reaction, but was part of the fundamental biochemistry of life.
More than a century later, NAD+ returned to the spotlight thanks to research into metabolism, mitochondria, cellular stress and ageing. Today, it is one of the most fascinating areas of research focused on healthy ageing.
Energy Starts Inside the Cell
NAD+ and NADH are important components of energy metabolism. They participate in the reactions that enable our cells to use nutrients and obtain energy from them.
Mitochondria also play a significant role in this process. These cellular structures are often described as the cell's "power plants". The connection between NAD+, energy metabolism and mitochondrial function is one of the reasons why this molecule is so interesting to longevity researchers.
Why Nicotinamide Riboside (NR)?
NAD+ itself and its precursor are not the same thing. Nicotinamide riboside (NR) is a form of vitamin B3 that the body can use as a building block to produce its own NAD+.
This is where modern research comes in. Human clinical studies have shown that oral NR supplementation can increase NAD+ levels in the blood. This is one of the main reasons why NR has become such an interesting ingredient in modern longevity supplementation.

What Do Human Studies Show?
One of the most interesting clinical findings comes from a randomised, double-blind, placebo-controlled study published in 2019. Researchers investigated the effects of different doses of nicotinamide riboside over an eight-week period.
At a dose of 300 mg of NR per day, NAD+ levels in whole blood increased by approximately 51%. At a dose of 100 mg, the increase was approximately 22%, while a dose of 1,000 mg resulted in an increase of 142%. The increases were already evident within the first two weeks and were maintained with continued supplementation.
Other clinical studies also indicate that longer-term NR supplementation may be well tolerated and can increase NAD+ metabolism in healthy middle-aged and older adults.
Beauty & Longevity NAD+ by Golden Life
These findings also provide the scientific background for Beauty & Longevity NAD+ by Golden Life.
One daily serving contains 300 mg of nicotinamide riboside chloride (NR). This dose was selected, among other considerations, in light of clinical data showing that 300 mg of NR per day can significantly increase NAD+ levels in human blood.
However, the formula is not based on NAD+ and NR alone. It also contains 6,000 mg of Peptan® F and a combination of other ingredients, including Q10, ALA, resveratrol, hyaluronic acid, MSM, vitamins and minerals.
BEAUTY + ENERGY + LONGEVITY
The modern approach to longevity looks beyond how we appear on the outside. It also considers nutrition, metabolism, cellular energy and the processes taking place inside our cells.
Discover Beauty & Longevity NAD+Longevity Is About More Than Appearance
The modern approach to beauty and longevity looks beyond the surface of the skin. It also focuses on nutrition, metabolism, cellular energy and protecting cells against oxidative stress.
That is why Beauty & Longevity NAD+ is designed as a daily morning ritual that combines beauty ingredients with ingredients associated with energy metabolism and antioxidants.
This is not just another ordinary collagen drink. It is a comprehensive daily supplement in a single sachet, bringing together the concepts of beauty, energy and longevity.

NAD+ Is Not an Elixir of Immortality
NAD+ is fascinating. However, it is important to distinguish scientific findings from marketing promises.
Research into NAD+ is advancing rapidly, but current science has not demonstrated that taking NR alone extends human lifespan. What is well established is that NAD+ is an important component of cellular metabolism and that oral NR supplementation can increase NAD+ levels in the blood.
It is precisely this combination of a strong biological foundation and ongoing research that makes NAD+ one of the most fascinating topics in modern longevity science.
What Should You Take Away from This?
NAD+ is not a new trendy molecule that appeared overnight. It is part of our body's fundamental biochemistry, and scientists have been studying its importance for more than a century.
Current research indicates that nicotinamide riboside can be an effective way to increase NAD+ levels in the body. This is why NR has become one of the most interesting substances in current healthy ageing and longevity research.
And if you want to think about longevity not only in terms of appearance, but also in terms of what happens inside your cells, NAD+ is a fascinating place to start.
References and Scientific Studies
This article is based on available scientific publications and Golden Life expert materials. Below are the main sources used for the section on NAD+ and nicotinamide riboside.
- Conze et al., 2019 – 100, 300 and 1,000 mg of NR per day
An eight-week randomised, double-blind, placebo-controlled study. At a dose of 300 mg of NR per day, NAD+ levels in whole blood increased by approximately 51%; the increase was 22% at 100 mg and 142% at 1,000 mg. The increase was evident within the first two weeks and was maintained with continued supplementation.
Study on PubMed → - Martens et al., Nature Communications, 2018
A randomised, double-blind crossover study in healthy middle-aged and older adults. The authors found that longer-term NR supplementation was well tolerated and stimulated NAD+ metabolism. The study also investigated potential cardiovascular effects, which should be interpreted as preliminary findings.
Full study in Nature Communications → - Trammell et al., Nature Communications, 2016 – How NR Contributes to NAD+ Production
One of the important early human studies. It showed that orally administered NR is bioavailable and affects the NAD+ metabolome. Single doses of 100, 300 and 1,000 mg were tested.
Study on PubMed → - NR in Older Adults – 2023
A placebo-controlled pilot study in older adults with mild cognitive impairment. At doses of up to 1 g of NR per day, the authors observed a 2.6-fold increase in blood NAD+. The study primarily focused on safety and was small, so no strong conclusions can be drawn about cognitive effects.
Study on PubMed → - A Comprehensive Review of NAD+ and Longevity
A review summarising the role of NAD+ metabolism in ageing and longevity. It covers energy metabolism, cellular processes, mitochondria and mechanisms associated with ageing.
Review on PubMed →
